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KMID : 1059520200640020067
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Journal of the Korean Chemical Society
2020 Volume.64 No. 2 p.67 ~ p.73
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Comparison of In Vitro Lipid Deposition and Change of Optical Characteristics on Daily Disposable Lenses (1-day) and 3-days Lenses Over 3 days
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Song Sun-Jung
Lee Su-Yeon
Kim Ki-Hong
Chu Byoung-Sun
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Abstract
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The study aimed to investigate in vitro lipid deposition of oleic acid, oleic acid methyl ester and cholesterol on a daily disposable (1-day lenses) and 3-days lenses over 3 days and changes of optical characteristics is also investigated. Artificial tear solutions were prepared to simulate actual tear compositions. Two types of contact lenses (1-day lenses (Senofilcon A) and 3- days lenses (silicone tripolymer)) were soaked in the artificial tear solutions within an incubator at 37 oC with 150 rpm for 8, 16, 24 hours. Lipid deposition (oleic acid, oleic acid methyl ester and cholesterol) were measured using high performance liquid chromatography (HPLC) instrument. In addition, measurements of oxygen transmissibility, light transmittance and observation of lens surface were conducted. The amount of lipid deposition on the 1-day lenses were 127.55 μg/lens for Day 1, 302.96 μg/lens, for Day 2, and 353.30 μg/lens for Day 3. The 3-days lenses were 46.22 μg/lens for Day 1, 66.07 μg/lens for Day 2, and 67.45 μg/lens for Day 3. Oxygen transmissibility were 81×10?9(cm/sec)(ml O2/ml×mmHg)(Baseline) and 48×10?9(cm/sec)(ml O2/ml×mmHg) (Day 3) for the 1-day lenses, it were 13.23×10?9(cm/sec)(ml O2/ml×mmHg)(Baseline) and 9.6×10?9(cm/sec)(ml O2/ml×mmHg) (Day 3) for the 3-days lenses. Transmittance of each lenses were 97.21% (Baseline) and 94.25% (Day 3) for the 1-day lenses, 97.65% (Baseline) and 95.15% (Day 3) for the 3-days lenses. Observation of surface deposition indicated greatest deposition for the 3-days lenses type on Day 3. Lipid deposition for both lens types increased by day and was greater for the 1-day lenses type. Surface deposition appeared to differ as it was greatest for the 3 days lens type, which may suggest other deposits such as protein may be present.
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KEYWORD
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ATS(artificial tear solution), HPLC(high performance liquid chromatography), Oxygen transmissibility, Visible light transmittance, SEM (scanning electron microscope)
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